Medicine & Biotechnology

The present invention provides vaccine compositions of attenuated dengue-4 virus. More specifically, the attenuated virus is produced by serial passage in PDK cells. The invention also provides methods for stimulating the immune system of an individual to induce protection against dengue-4 virus by administration of attenuated dengue-4 virus.

A reusable sponge or foam made of a polymer such as polyurethane is prepared containing a plurality of different enzymes or a cross-linked complex of the plurality of enzymes for detoxification of a diverse array of hazardous chemicals such as organophosphorus and/or organosulfur compounds. The plurality of enzymes include enzymes selected from acetylcholinesterase, butyrylcholinesterase, triesterase, pseudocholinesterase, choline oxidase, peroxidase, organophosphate hydrolase, phosphotriesterase, paraoxonase and laccase.

A method for fluorescence probing of particles flowing in a fluid includes defining a trigger volume in the fluid by intersecting a plurality of substantially orthogonally aimed trigger laser beams, each of a different wavelength, detecting light scattered from the vicinity of the trigger volume by a plurality of particle detectors each sensitive to a wavelength corresponding to the wavelength of a trigger laser beam, probing the particles with a pulsed laser triggered by the particle detectors, collecting fluorescence emitted from the particle in a detection volume and focusing it in a detect

A device for securing a catheter with respect to a patient's mouth that preferably includes a balloon that can be inflated within the patient's mouth on the exterior of the catheter, a bite block, and a shield. The balloon preferably immobilizes the catheter with respect to the securing device when inflated while permitting relative movement of the catheter and the securing device when deflated. The balloon preferably also prevents inadvertent withdrawal of the securing device from the patient's mouth when inflated while permitting withdrawal when deflated.

The invention provides novel methods of detoxifying highly toxic chemicals, and treating surfaces contaminated, or potentially contaminated, with toxic chemical agents such as chemical warfare agents and/or industrial toxins. The methods employ silver-exchanged zeolites and sodium zeolites as reactive sorbents to degrade such agents or toxins on contact, in solution or vapor form.

Compounds, compositions and methods are provided for treating malaria parasites in vitro and in vivo by administering indolo[2,1-b]quinazoline-6,12-dione compounds of Formula I.

People can be taught to control voluntarily their own alpha rhythms. This can be used to send messages in Morse code and printed out by printer when an electroencephalogram pattern is processed by an appropriate computer program. Such procedures can also be used as control signals to activate servomechanisms any other device or appliance.

An apparatus and method for predicting cognitive performance of an individual based on factors including preferably sleep history, the time of day, and the individual's activities. The method facilitates the creation of predicted cognitive performance curves that allow an individual to set his/her sleep times to produce higher levels of cognitive performance. The method also facilitates the reconstruction of past cognitive performance levels based on sleep history.

A controlled release microcapsule pharmaceutical formulation for burst-free, sustained, programmable release of a non-steroidal, antiinflammatory drug over a duration from 24 hours to 2 months, comprising: a non-steroidal, antiinflammatory drug and a blend of biocompatible, biodegradable poly (lactide/glycolide).

The present invention provides immunogenic compositions of attenuated dengue-1 virus. More specifically, the attenuated virus is produced by serial passage in PDK cells. The invention also provides methods for stimulating the immune system of an individual to induce protection against dengue-1 virus by administration of attenuated dengue-1 virus.