Army

Antimicrobial Peptide in Antiplaque Chewing Gum

Augment our natural immune responses. Prevent & disrupt biofilm formation. Target plaque related oral diseases.

Medical & Biotechnology

Data ImageKSL-W is a member of a decapeptide family with demonstrated effectiveness to prevent biofilm formation on teeth, inhibit the growth of oral microorganisms, and reduce the development of plaque or dental caries. KSL-W mimics the body’s own defense system – namely it exhibits selective toxicity for prokaryotes. The result is efficacy against supragingival plaque bacteria, but little effect on normal oral flora and low potential for drug-resistance. KSL–W is readily adsorbed to toothlike materials and effectively desorbed over time; this peptide also has good stability in saliva.

The U.S. Army Dental and Trauma Research Detachment has formulated this peptide into an antiplaque chewing gum (APCG) for sustained and improved delivery in the mouth. In addition to KSL–W, APCG contains a xylitol base, calcium phosphate as a mild abrasive, and cetylpyridinium chloride which causes a large increase in the rate and extent of KSL–W release. This peptide readily degrades in gastric environments. APCG has extensive pre-clinical testing data and is funded to enter FDA Phase I trials.

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